Veranstaltungen

20. Mai 2025, 16:00 bis 17:00

Cédrik Barutel, TU Wien, IAP, FB Biophysik

Seminar

Thermodynamic consistent theory of crosslinkers on biological filaments

The cytoskeleton is the intracellular structure that enables cellular motion and essential cell-mechanical processes like cell division and chromosome segregation. It consists of filaments (actin, microtubules, intermediate filaments) that are connected by motor proteins and passive crosslinkers. Biologists and biochemists have uncovered and characterized many of the constituent proteins of the cytoskeleton. However, we are still lacking a deeper understanding of how the collective behavior of these parts working together emerges.

We know that filaments and crosslinkers organize into a dynamic network that keeps itself out of thermodynamic equilibrium by consuming chemical energy from the cellular environment. I aim to develop an out-of-equilibrium thermodynamic theory for understanding the forces that crosslinking proteins exert collectively between two filaments that they couple. More precisely, I will study the non-equilibrium statistical mechanics of a gas of motor (active) and non motor (passive) proteins on 1D manifolds (filaments). This will allow me to take a phenomenology view, which will complement more traditional agent based approaches. Using a phenomenology approach will allow me to be general - since I can write a complete thermodynamic consistent theory from conservation laws and symmetry principles alone - and thus simplify the exploration of different collective behaviors of the crosslinking proteins regardless of microscopic details. In this seminar I’ll demonstrate how this theory is applied to a specific biological system consisting of actin filaments connected by anillin, an actin passive crosslinkers.

Kalendereintrag

Veranstaltungsort

SEM.R. DB gelb 05 B
1040 Wien
Wiedner Hauptstraße 8-10/E134

 

Veranstalter

IAP
Manuela Marik
marik@iap.tuwien.ac.at

 

Öffentlich

Ja

 

Kostenpflichtig

Nein

 

Anmeldung erforderlich

Nein